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Check Intently (three)pentobarbital will minimize the extent or influence of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Strong or average CYP3A4 inducers might raise rate of diazepam elimination; thus, efficacy of diazepam may very well be lowered.Barbiturates can induce hepatic microsomal enz